Hydrochloric Acid → HCID 21336752, compound

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Reaction Steps

The compound was prepared by coupling of allyl bromide with 1-[(-3,4-dichlorophenyl)acetyl]-2-(R)-[(1-pyrrolidinyl)methyl]piperazine in 81% yield; mp: (HCl salt) 157-160° C.; 1H NMR (free base, 200 MHz, CDCl3) δ 1.4-2.0 (6H, m), 2.3-3.0 (6H, m), 3.1-3.8 (4H, m), 4.3-4.8 (1H, m), 4.9-5.1 (2H, m), 5.7-5.9 (1H, m), 7.0-7.73 (3H, m); MS (FAB) 396 (M+H)+; Anal. Calcd for C20H27Cl2N30.2HCl: C, 51.19; H, 6.23; N, 8.95. Found: C, 50.89; H, 6.42; N, 8.65.

Provenance & Evidence