HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanethiolate → Methyl 2-(methylthio)-4-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | Methyl 2-chloro-4-(trifluoromethyl)benzoate | HCID 23499962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Methyl 2-(methylthio)-4-(trifluoromethyl)benzoate | HCID 10944828 | 94.5% |
Reaction Steps
Dry sodium thiomethoxide (0.385 g, 0.0055M) was added to a solution of methyl 2-chloro-4-trifluoromethylbenzoate (1.19 g, 0.005M) in anhydrous N-methylpyrrolidinone (10 ml) at 5° C. After 3 hours the mixture was acidified, extracted (ether), washed (water) and evaporated to give methyl 2-methylthio-4-trifluoromethylbenzoate (1.18 g, 94% yield), 1H NMR 2.44(s,3H), 3.89(s,3H), 7.33(1H), 7.41(1H), 8.02(1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486356B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-9db295afc527454e99be3521ae7989a5 |
| Source note | uspto-grants-2002_11 |