Water → HCID 86758622, compound

Participants

Reaction Conditions

Reaction Steps

The compound obtained in Example 5 (200 mg) is dissolved in dimethyl formamide (20 ml), and thereto are added potassium carbonate (92 mg), and 2-picolyl chloride hydrochloride (55 mg). The mixture is stirred at 60° C. overnight, and thereto are added water and ethyl acetate. The ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent, hexane:ethyl acetate=1:2) to give 2-[4-(tert-butoxycarbonylamino)phenyl]-6-methoxy-3-methoxy-carbonyl-7-(2-pyridylmethyloxy)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (207 mg).

Provenance & Evidence