Morpholine → HCID 53817948, compound

Participants

Reaction Steps

A solution of the compound obtained in Example 21 (200 mg), 1-hydroxybenzotriazole (69 mg) and 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (86 mg) in methylene chloride (10 ml) is stirred at room temperature for 30 minutes. To the mixture is added a solution of morpholine (71 mg) in methylene chloride (2 ml), and the mixture is stirred at room temperature overnight. After the reaction is complete, to the mixture are added water and ethyl acetate. The ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure. The residue is crystallized from diethyl ether to give 3-methoxycarbonyl-2-[4-(morpholinocabonyl) phenyl]-4-(3,4,5-trimethoxyphenyl)-1(2H) isoquinolinone (210 mg) as listed in Table 4.

Provenance & Evidence