tert-Butyl carbazate → HCID 54430975, compound

HRID 1019377Notes

Reaction equation

[Na].[C:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:19]([C:25]3[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[C:27]([O:35][CH3:36])[CH:26]=3)[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:37])=[CH:7][CH:6]=1)([OH:4])=O.[C:38]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])(=[O:41])[NH:39][NH2:40]>>[C:43]([O:42][C:38]([NH:39][NH:40][C:2]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:19]([C:25]3[CH:26]=[C:27]([O:35][CH3:36])[C:28]([O:33][CH3:34])=[C:29]([O:31][CH3:32])[CH:30]=3)[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:37])=[CH:9][CH:10]=1)=[O:4])=[O:41])([CH3:46])([CH3:45])[CH3:44]

Participants

Reactant 2

HCID 70091tert-Butyl carbazate

HCID 70152632HCID 70152632, compound

Product 1

HCID 54430975HCID 54430975, compound

Procedure

The compound obtained in Example 21 and tert-butyl carbazate are treated in the same manner as in Example 22 to give 2-[4-(tert-butoxycarbonylhydrazinocarbonyl)phenyl]-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 4.

Sources & evidence

ORD record: ord-c6c0524ebee8400c9b0f871048696902
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06486155B1

Reaction notes

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