Pyridine → HCID 18399207, compound

Participants

Reaction Steps

To a solution of the compound obtained in Example 68 (200 mg) and pyridine (120 mg) in tetrahydrofuran (15 ml) is added dropwise a solution of acetyl chloride (61.3 mg) in tetrahydrofuran (5 ml) under ice-cooling, and the mixture is stirred under ice-cooling for one hour, and further stirred at room temperature overnight. To the reaction mixture are added ethyl acetate and water, and the ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure. The residue is crystallized from a mixture of hexanediethyl ether to give 2-acetylamino-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (116 mg) as listed in Table 6.

Provenance & Evidence