Chloroform → HCID 18399107, compound

Participants

Reaction Steps

The compound obtained in Example 67 (1.00 g) is dissolved in dimethylformamide (10 ml), and thereto are added potassium carbonate (382 mg) and methyl iodide (392 mg). The mixture is stirred at room temperature overnight, and thereto are added chloroform and water. The chloroform layer is separated, washed, dried, and concentrated under reduced pressure. The residue is crystallized from diethyl ether to give 3-methoxycarbonyl-2-(N-methyl-N-tert-butoxycarbonylamino)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 6, which is used as a starting compound in Example 72 without further purification.

Provenance & Evidence