Hydrochloric Acid → HCID 18399015, compound

Participants

Reaction Steps

To a solution of the compound obtained in Example 73 (170 nig) in dioxane (1 ml) is added a 4M solution of hydrogen chloride in dioxane (10 ml), and the mixture is stirred at room temperature for three hours. The reaction mixture is concentrated under reduced pressure, and the residue is dissolved in ethyl acetate. The mixture is washed with water, dried, and concentrated under reduced pressure. The residue is purified by Chromatotron (solvent; chloroform:acetone=5:1), and crystallized from diethyl ether to give 2-[-(2-hydroxyethyl)amino]-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 6.

Provenance & Evidence