Hydrochloric Acid → HCID 18399029, compound

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Reaction Steps

A mixture of the compound obtained in Example 118 (1.3 g), conc.hydrochloric acid (15 ml) and dioxane (15 ml) is heated under reflux overnight. The reaction mixture is cooled to room temperature, and thereto are added water and chloroform. The extract is washed, dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform:acetone=50:1) to give 6,7-dimethoxy-4-(3,5-dimethoxy-4-hydroxyphenyl)-3-methoxycarbonyl-2-morpholino-1(2H)-isoquinolinone (530 mg) as listed in Table 10.

Provenance & Evidence