Morpholine → HCID 70137744, compound

Participants

Reaction Steps

A solution of the compound obtained in Example 128 (1.50 g), 1,3-dicyclohexylcarbodiimide (793 mg) and 1-hydroxybenzotriazole (588 mg) in dimethylformamide (30 ml) is stirred at room temperature for one hour, and thereto is added morpholine (335 mg), and the mixture is stirred for two hours. The mixture is further stirred at 50° C. for four hours. To the reaction mixture are added water and ethyl acetate. The ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure. The residue is crystallized from diethyl ether-ethyl acetate to give 6,7-dimethoxy-2-methyl-3-morphlino-carbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (893 mg) as listed in Table 12.

Provenance & Evidence