Formic Acid → HCID 18399233, compound

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Reaction Steps

To formic acid (3 ml) is added acetic anhydride (3 ml), and the mixture is stirred at room temperature for four hours. To the reaction mixture is added the compound obtained in Example 176 (500 mg), and the mixture is stirred at room temperature overnight. The mixture is further stirred at 60° C. overnight. After the reaction is complete, to the reaction mixture are added water and ethyl acetate. The ethyl acetate layer is separated, washed with water, dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform:acetone=10:1) to give 6,7-dimethoxy-2-[3-(formylamino)phenyl]-4-(3-bromo-4,5-dimethoxyphenyl)-3-methoxycarbonyl-1(2H)-isoquinolinone as listed in Table 16.

Provenance & Evidence