Triethylamine → HCID 18399297, compound

Participants

Reaction Steps

To a solution of the compound obtained in Example 184 (190 mg) in dimethylformamide (3 ml) are added nicotinoyl chloride (69 mg) and triethylamine (0.11 ml), and the mixture is stirred at room temperature overnight To the reaction mixture are added nicotinoyl chloride (69 mg) and triethylamine (0.11 ml), and the mixture is stirred overnight. After the reaction is complete, to the mixture are added ethyl acetate and water. The ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure to give 4-(3-bromo-4,5-dimethoxyphenyl)-6,7-dimethoxy-3-methoxycarbonyl-2-[3-(nicotinoyloxy)propyl]-1(2H)-isoquinolinone (170 mg) as listed in Table 16.

Provenance & Evidence