Potassium Carbonate → HCID 18399283, compound

Participants

Reaction Steps

Pyrrol-2-carboxylic acid (38.4 mg) and 1-hydroxybenzotriazole monohydrate (53 mg) are dissolved in acetonitrile (10 ml), and thereto is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (66.3 mg), and the mixture is stirred at room temperature for 30 minutes. The reaction mixture is added to a solution of the compound obtained in Example 214 (162 mg) and potassium carbonate (48 mg) in dimethylformamide (10 ml), and the mixture is stirred at room temperature for 30 minutes. Water and ethyl acetate are added to the reaction mixture. The ethyl acetate layer is separated, washed, dried, and concentrated under reduced pressure. The residue is crystallized from diethyl ether to give 6-methoxy-3-methoxycarbonyl-2-phenyl-7-(2-pyrrolylcarbonyloxy)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (145 mg) as listed in Table 18.

Provenance & Evidence