2-Bromopyridine → HCID 18398987, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of the compound obtained in Example 5 (300 mg), 2-bromopyridine (57 μl), copper iodide (113 mg) and potassium carbonate (82 mg) in dimethylformamide (5 μl) is heated with stirring at 80° C. for five hours. After the reaction is complete, the reaction mixture is extracted with ethyl acetate. The extract is washed with aqueous ammonia, and further washed with water, dried, and concentrated under reduced pressure. The residue is purified by Chromatotron (solvent; hexane:ethyl acetate=1:1) to give 2-[4-(tert-butoxycarbonylamino)phenyl]-6-methoxy-3-methoxycarbonyl-7-(2-pyridyloxy)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (40 rag) as listed in Table 20.

Provenance & Evidence