Triethylamine → HCID 18399379, compound

Participants

Reaction Steps

The compound obtained in Example 5 (200 mg) is dissolved in dimethylformamide (10 ml), and thereto are added benzochloride (40 μl), triethylamine (48 μl) and 4-dimethylaminopyridine (5 mg), and the mixture is stirred at room temperature overnight. After the reaction is complete, to the mixture is added a saturated aqueous sodium hydrogen carbonate solution, and the mixture is extracted with ethyl acetate. The extract is washed, dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; hexane:ethyl acetate=1:1) to give 7-benzoyloxy-2-[4-(tert-butoxycarbonylamino)phenyl]-6-methoxy-3-methoxycarbonyl-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 20.

Provenance & Evidence