Triethylamine → HCID 18399312, compound

Participants

Reaction Steps

A solution of the compound obtained in Example 5 (100 mg) and triethylamine (50 mg) in chloroform (10 ml) is cooled to −10° C., and thereto is added dropwise a solution of triphosgene (49 mg) in chloroform. The mixture is warmed to room temperature, and the mixture is stirred for 30 minutes. To the mixture is added a solution of N-methylpiperazine (50 mg) and triethylamine (17 mg) in chloroform, and the mixture is further stirred for two hours. After the reaction is complete, the reaction mixture is washed, dried, and concentrated under reduced pressure. The residue is crystallized from diethyl ether to give 2[4-(tert-butoxycarbonylamino)phenyl]-6-methoxy-3-methoxycarbonyl-7-(4-methylpiperazinylcarbonyloxy)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone (73 mg) as listed in Table 20.

Provenance & Evidence