Trifluoroacetic acid → HCID 18398857, compound

Participants

Reaction Steps

To a solution of the compound obtained in Example 67 (5.60 g) in methylene chloride (15 ml) is added trifluoroacetic acid (15 ml), and the mixture is allowed to stand at room temperature for three hours. After the reaction is complete, the reaction mixture is concentrated under reduced pressure. The resulting residue is dissolved in ethyl acetate, and extracted. The extract is washed, dried, and concentrated under reduced pressure. The resulting residue is crystallized from ethyl acetate to give 3-methoxycarbonyl-2-(trifluoroacetyl-amino)-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone as listed in Table 24.

Provenance & Evidence