HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 22482947, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Efaproxiral | HCID 122335 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Alanine methyl ester hydrochloride | HCID 2733257 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | HCID 15907885 | HCID 15907885 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22482947 | HCID 22482947 | — |
Reaction Steps
Using RSR13 acid (1.4 g, 4.1 mmol), appropriate (D or L) alanine methyl ester hydrochloride (575 mg, 4.1 mmol) and 1-hydroxybenzotriazole hydrate (610 mg, 4.5 mmol), N-methylmorpholine (622 mg, 6.2 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (946 mg, 4.9 mmol) in dimethylformamide (30 mL), the two isomers were prepared and isolated as described above for compound 21, in 1.67 g yield (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486342B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-1f77e0fb69db4d18a3c4b563119c38ba |
| Source note | uspto-grants-2002_11 |