HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 22482962, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Efaproxiral | HCID 122335 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22482962 | HCID 22482962 | — |
Reaction Steps
Using RSR13 acid (3.08 g, 9.0 mmol), proline methyl ester hydrochloride (1.5 g, 9.0 mmol) and 1-hydroxybenzotriazole hydrate (1.34 g, 9.9 mmol), N-methylmorpholine (1.37 g, 13.6 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.08 g, 10.8 mmol) in dimethylformamide (40 mL), the product was prepared in 3.9 g yield (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06486342B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-8f91a81d87d04d56a2eebffac3d500a2 |
| Source note | uspto-grants-2002_11 |