alpha-Hydroxyacetophenone → Cinnamoylbenzene

Participants

Reaction Steps

2.29 g (16.8 mmol) of 2-hydroxyacetophenone, 1.8 g of thiazole-2-carbaldehyde (15.9 mmol), and 10 ml of 25% wt NaOCH3 were reacted in 50 ml of dry THF to give 0.254 g (27%) of chalcone after purification. 1H NMR (300 MHz, CDCl3): δ 12.62 (s, 1H), 8.08-7.94 (m, 4H), 7.57-7.51 (m, 2H), 7.06 (d, d, J=1.2, 8.4 Hz, 1H), 6.98 (d, d, d, J=1.2, 7.2, 8.1 Hz, 1H).

Provenance & Evidence