1,2-Ethanediamine, N1,N1,N2-trimethyl- → 1-((2-(Dimethylamino)ethyl) (methyl)amino)-5-(2-(dimethylamino) ethylamino)anthracene-9,10-dione

HRID 1019489ノート

反応式

HRID 1019489 の反応式
Cl[C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[C:9]([NH:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[CH:10]=[CH:11][CH:12]=3)[C:7](=[O:23])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][NH:28][CH3:29]>>[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][N:28]([CH3:29])[C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[C:9]([NH:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[CH:10]=[CH:11][CH:12]=3)[C:7](=[O:23])[C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 143201251-Chloro-5-(2-(dimethylamino)ethylamino)anthracene-9,10-dione

生成物 1

HCID 592291271-((2-(Dimethylamino)ethyl) (methyl)amino)-5-(2-(dimethylamino) ethylamino)anthracene-9,10-dione収率 43.4%

実験手順

This procedure was carried out as described previously in Example 19, using Compound 17 (500 mg, 1.52 mmol) and N,N,N′-trimethylethylenediamine (988 μL, 7.6 mmol). The dye was obtained as a red solid (260 mg) after Biotage purification using a gradient of methanol in chloroform. Abs (max, PBS pH 7.4)=530 nm; Em=646 nm. The structure of Compound 41 is given below:

出典と根拠

ORDレコード
ord-ad501799f6d14ba1a63371006a21a86c
出典データセット
uspto-grants-2014_05
特許番号
US08715944B2

反応ノート

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