HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfamide → Sulfamic acid chroman-2-ylmethyl amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfamide | HCID 82267 | — |
| Reactant | 1-(3,4-dihydro-2H-1-benzopyran-2-yl)methanamine | HCID 11263686 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Sulfamic acid chroman-2-ylmethyl amine | HCID 11230247 | — |
Reaction Steps
The oily amine (1.63 g, 10 mmol) and sulfamide (1.92 g, 20 mmol) were combined in dioxane (50 mL) and brought to reflux for 2 h. The solution was cooled and evaporated in vacuo to yield an oil, which was purified via column chromatography (DCM:Methanol 10:1) to yield a white solid. The solid was recrystallized from ethyl acetate/hexane to yield chroman-2-ylmethylsulfamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716231B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7d23da7f06bb435c8177cfaf5f03ed59 |
| Source note | uspto-grants-2014_05 |