Dapagliflozin → HCID 131728579, compound

HRID 1019511Notes

Reaction equation

HRID 1019511 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:8][CH:9]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]>>[CH3:1][CH2:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:6][CH:5]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]

Participants

3

Reactant 2

HCID 9887712DapagliflozinHCID 56841155HCID 56841155, compound

Product 1

HCID 131728579HCID 131728579, compound

Procedure

Tablets containing the SGLT2 inhibitor dapagliflozin or dapagliflozin propylene glycol hydrate were prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9) as described below.

Workup

  1. customwere prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9)

Sources & evidence

ORD record
ord-3298eb4ef70944ef979486109caef090
Source dataset
uspto-grants-2014_05
Patent number
US08716251B2

Reaction notes

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