Borane;tetrahydrofuran → HCID 58256115, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product from step (d) (2.5 g, 9.33 mmol) in THF (85 ml) was cooled to 0° C. and a 1M solution of BH3-THF (46.6 ml, 46.6 mmol) was added dropwise over 10 min. and stirred for an additional 20 minutes after the addition was complete. The reaction was warmed to 22° C. and stirred for 2 hours. The reaction was poured into ice cold sat. NaHCO3 (150 ml) and extracted with EtOAc. The crude was passed through a plug of silica gel washing with EtOAc. Concentration of the eluent provided 1.99 g (88%) of the subtitle compound.

Provenance & Evidence