Hydrogen Bromide → 5-Bromoazepan-4-one hydrobromide

Participants

Reaction Steps

27 mL 33% HBr solution was added to 20 g hexahydro-azepin-4-one hydrochloride in 225 mL conc. acetic acid. Subsequently 6.9 mL bromine in 25 mL conc. acetic acid was added dropwise to the reaction mixture and the mixture was stirred 30 min at RT. The solvent was removed and the residue was crystallized with acetonitrile to give 27.9 g of the desired compound.

Provenance & Evidence