HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2-[1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-methyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrobromide | HCID 86687941 | — |
| Reactant | (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt | HCID 89620421 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[1,4-Bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone | HCID 71604266 | 44.8% |
Reaction Steps
38 mg 2-methyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrobromide was added to 40 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt, 45 mg TBTU, 0.06 mL DIPEA in 0.75 mL DMF. The reaction was stirred over night at RT. Water was added to the reaction and the mixture was stirred 1 h. The precipitate was filltered and dried to give 26 mg desired product. Rt: 4.59 (method E), (M+H)+: 465
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716277B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-30fb56a5f8984f59b4801a664d1d5098 |
| Source note | uspto-grants-2014_05 |