HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → HCID 56932852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | trans-3-(3-Pyridyl)acrylic acid | HCID 776396 | — |
| Reactant | HCID 58055425 | HCID 58055425 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 56932852 | HCID 56932852 | — |
Reaction Steps
The title compound was prepared in two steps according to Scheme 5 by (1) treating amine VII with (E)-3-pyridin-3-yl-acrylic acid, EDCI, HOBt, and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 338.1, exp (MH+) 338.4. 1H NMR (CD3OD, 400 MHz), 9.07 (s, 1H), 8.82 (m, 2H). 8.11 (m, 1H), 7.7 (m, 1H, J=15.6 Hz), 7.52 (m, 2H), 7.22 (m, 1H), 7.7 (d, 1H, J=16 Hz), 4.29 (m, 1H), 2.8-3.2 (m, 4H), 2.25 (m, 1H), 1.9 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716285B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-cc252db80cd04a319e7a7b66dfeb55c3 |
| Source note | uspto-grants-2014_05 |