Hydroxylamine → HCID 56932907, compound

Participants

Reaction Steps

The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with 3-fluorobenzenesulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 365, exp (MH+) 365.4. 1H NMR (CD3OD, 400 MHz), 7.75 (d, 1H, J=8.0 Hz), 7.60-7.66 (m, 2H), 7.46 (d, 1H, J=8.0 Hz), 7.41 (m, 1H), 7.36 (s, 1H), 7.14 (d, 1H, J=8.0 Hz), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).

Provenance & Evidence