Hydroxylamine → HCID 56932909, compound

Participants

Reaction Steps

The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with 3-chlorobenzenesulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 381, exp (MH+) 381. 1H NMR (CD3OD, 400 MHz), 7.90 (m, 1H), 7.84 (d, 1H, J=8.0 Hz), 7.66 (d, 1H, J=8.4 Hz), 7.59 (t, 1H, J=8.0 Hz), 7.47 (d, 1H, J=8.0 Hz), 7.36 (s, 1H), 7.15 (d, 1H, J=8.0 Hz), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).

Provenance & Evidence