Hydroxylamine → HCID 56932910, compound

Participants

Reaction Steps

The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with 3-trifluoromethyl-benzenesulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 415, exp (MH+) 415.4. 1H NMR (CD3OD, 400 MHz), 8.20 (s, 1H), 8.18 (d, 1H, J=8.8 Hz), 7.97 (d, 1H, J=8.0 Hz), 7.82 (t, 1H, J=7.6 Hz), 7.46 (d, 1H, J=7.6 Hz), 7.36 (s, 1H), 7.15 (d, 1H, J=8.0 Hz), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).

Provenance & Evidence