Hydroxylamine → HCID 56932957, compound

Participants

Reaction Steps

The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with 3,4-dimethoxybenzenesulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 407, exp (MH+) 407.5. 1H NMR (CD3OD, 400 MHz), 7.51 (dd, 1H, J1=8.4 Hz, J2=2.0 Hz), 7.46 (d, 1H, J=8.0 Hz), 7.42 (d, 1H, J=1.6 Hz), 7.35 (s, 1H), 7.11 (m, 2H), 3.92 (s, 3H), 3.88 (s, 3H), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).

Provenance & Evidence