HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → HCID 56932958, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzenesulfonyl chloride, 2,4-dichloro- | HCID 204419 | — |
| Reactant | HCID 58055425 | HCID 58055425 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 56932958 | HCID 56932958 | — |
Reaction Steps
The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with 2,4-dichlorobenzenesulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 415, exp (MH+) 415.3. 1H NMR (CD3OD, 400 MHz), 8.09 (d, 1H, J=8.4 Hz), 7.70 (d, 1H, J=2.0 Hz), 7.54 (dd, 1H, J1=8.4 Hz, J2=2.0 Hz), 7.46 (d, 1H, J=8.0 Hz), 7.33 (s, 1H), 7.14 (d, 1H, J=8.0 Hz), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716285B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-6b215ba6f15f455cb139d920d96614f7 |
| Source note | uspto-grants-2014_05 |