Hydroxylamine → HCID 56932960, compound

Participants

Reaction Steps

The title compound was prepared in two steps according to Scheme 6 by (1) treating amine VII with pyridine-3-sulfonyl chloride and TEA in dichloromethane, and (2) treating the ester intermediate with aqueous HONH2 and KOH. MS: calc'd (MH+) 348, exp (MH+) 348.4. 1H NMR (CD3OD, 400 MHz), 9.05 (s, 1H), 8.80 (d, 1H, J=4.4 Hz), 7.31 (d, 1H, J=8.0 Hz), 7.65 (m, 1H), 7.47 (d, 1H, J=8.0 Hz), 7.36 (s, 1H), 7.16 (d, 1H, J=8.0 Hz), 3.55 (m, 1H), 2.95 (m, 2H), 2.82 (m, 1H), 2.69 (m, 1H), 1.95 (m, 1H) 1.73 (m, 1H).

Provenance & Evidence