HCID 66679578, compound → HCID 58164229, compound

HRID 1019680Notes

Reaction equation

HRID 1019680 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[O:11][CH2:10][C:9]([C:15]([OH:17])=[O:16])=[CH:8]2)=[O:4]>CO>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[O:11][CH2:10][CH:9]([C:15]([OH:17])=[O:16])[CH2:8]2)=[O:4]

Participants

3

Reactant 1

HCID 66679578HCID 66679578, compound

Product 1

HCID 58164229HCID 58164229, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of ester XXXII (2 g, 8.5 mmol) and 300 mg of Pd (OH)2 in 20 mL of MeOH was stirred in an autoclave at 80° C. for 48 h under 40 psi of H2. Then the reaction mixture was filtered, and concentrated to give 1.7 g of chroman-3,6-dicarboxylic acid 6-methyl ester XXXIII (Yield 85%). MS: calc'd 237 (MH+), exp 237 (MH+).

Workup

  1. filtrationThen the reaction mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b6b08a7643f8444f8ed09ad3286762ab
Source dataset
uspto-grants-2014_05
Patent number
US08716285B2

Reaction notes

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