Ethyl Acetate → HCID 86663122, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of XXXIV (100 mg, 0.48 mmol), 2-chloro-5-pyridin-3-yl-pyrimidine (96 mg, 0.5 mmol) and TEA (137 μl, 1 mmol) in 2 mL of DMF was stirred at 150° C. for 1 h in a microwave reactor. The mixture was worked up with brine and EtOAc, and the organic phase was dried over Na2SO4, filtered, and evaporated in vacuo. Purification by silica gel column gave 80 mg of 3-(5-pyridin-3-yl-pyrimidin-2-ylamino)-chroman-6-carboxylic acid methyl ester XXXXIII (Yield 44%). MS: calc'd 363 (MH+), exp 363 (MH+).

Provenance & Evidence