反应详情

The process is performed according to the procedure described in Example 1 (step 1.6.). Starting with 0.23 g (0.5 mmol) of 4-nitrophenyl 2-[5′-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]ethylcarbamate, described in Example 1 (step 1.5.), 0.128 g (0.99 mmol) of N,N-diisopropylethylamine, 0.030 g (0.25 mmol) of N,N-dimethylaminopyridine and 0.067 g (0.50 mmol) of 3-ethyl[1,2,4]oxadiazol-5-ylmethanol, and after chromatography on silica gel, eluting with a 99/1/0.1 mixture of dichloromethane, methanol and 28% aqueous ammonia, 0.138 g of pure product is obtained in the form of a white powder.

1. washafter chromatography on silica gel, eluting with a 99/1/0.1 mixture of dichloromethane, methanol and 28% aqueous ammonia