Diisopropylethylamine → 4-Carbamoyloxazol-2-ylmethyl 2-[5'-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]ethylcarbamate

Participants

Reaction Steps

The process is performed according to the procedure described in Example 4. Starting with 0.25 g (0.54 mmol) of 4-nitrophenyl 2-[5′-(4-fluorophenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]ethylcarbamate, described in Example 1 (step 1.5.), 0.139 g (1.08 mmol) of N,N-diisopropylethylamine, 0.033 g (0.27 mmol) of N,N-dimethylaminopyridine and 0.084 g (0.59 mmol) of 4-carbamoyloxazol-2-ylmethanol, prepared in step 5.2., 0.162 g of pure product is obtained in the form of a white powder.

Provenance & Evidence