tert-Butyl 4-aminomethyl-4-fluoropiperidine-1-carboxylate → tert-Butyl 4-[(3-ethoxycarbonylisoxazol-5-ylmethoxy-carbonylamino)methyl]-4-fluoropiperidine-1-carboxylate

Participants

Reaction Steps

The process is performed according to the procedure described in Example 1 (step 1.6.). Starting with 0.70 g (3.01 mmol) of tert-butyl 4-aminomethyl-4-fluoropiperidine-1-carboxylate (commercial) and 1.11 g (3.31 mmol) of ethyl 5-(4-nitrophenoxycarbonyloxymethyl)isoxazole-3-carboxylate, obtained in step 14.1., 0.33 g of pure product is obtained in the form of an orange-coloured oil.

Provenance & Evidence