Ethyl chloroformate → Ethyl [2-(5'-bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)ethyl]carbamate

Participants

Reaction Steps

The process is performed according to the method described in Example 1 (step 1.5.). Starting with 4.52 g (15.90 mmol) of 2-(5′-bromo-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-ethylamine, prepared in step 10.2., 1.89 g (17.49 mmol) of ethyl chloroformate, 5.13 g (39.76 mmol) of N,N-diisopropylethylamine and 0.19 g (1.59 mmol) of N,N-dimethylaminopyridine, and after purifying on a column of silica gel, eluting with a 99/1/0.1 mixture of dichloromethane, methanol and 28% aqueous ammonia, 3.87 g of expected product are obtained in the form of a powder.

Provenance & Evidence