HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66660798, compound → HCID 66661197, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66660798 | HCID 66660798 | — |
| Reactant | HCID 178418816 | HCID 178418816 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66661197 | HCID 66661197 | — |
Reaction Steps
The process is performed according to the procedure described in Example 18 (step 18.1.). Starting with 5.00 g (16.99 mmol) of tert-butyl 4-(cyanoethoxycarbonylmethylene)piperidine-1-carboxylate (WO 2006/001 752) in 56 mL of tetrahydrofuran, and 16.99 mL (33.97 mmol) of a 2M solution of isobutylmagnesium bromide in ether, 1.46 g of pure product are obtained in the form of a wax.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716289B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-20f599c8daca42ceaf82d8791714ed17 |
| Source note | uspto-grants-2014_05 |