HCID 66660976, compound → HCID 66660862, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 12 (step 12.2.). Starting with 1.10 g (3.95 mmol) of tert-butyl 4-cyanomethyl-4-isobutylpiperidine-1-carboxylate and 1.16 g (19.75 mmol) of Raney nickel in 13 mL of methanol under a hydrogen atmosphere (70 psi), at 45° C. and after chromatography on a column of silica gel, eluting with a 96/4/0.4 mixture of dichloromethane, methanol and 28% aqueous ammonia, 0.50 g of expected product is obtained in the form of an oil.

Provenance & Evidence