反应详情

A scintillation vial equipped with a stirbar was charged with (S)-6-vinyl-1-(1-phenylethyl)-1H-imidazo[4,5-b]pyrazin-2-ol (1.0 equiv), methanol (280 volume equivalents), and catalytic Pd/C. The resulting mixture was purged with hydrogen for 45 minutes; the reaction was complete as judged my LCMS. The mixture was then filtered through a pad of diatomaceous earth and the pad of diatomaceous earth was washed twice with MeOH. The solution was concentrated in vacuo. Flash chromatography (Biotage MPLC 5%-40% EtOAc/Hexanes) provided the title compound (86%) as a foam. LCMS m/z (APCI)=269.1 (M+H).

1. customA scintillation vial equipped with a stirbar
2. customThe resulting mixture was purged with hydrogen for 45 minutes
3. filtrationThe mixture was then filtered through a pad of diatomaceous earth
4. washthe pad of diatomaceous earth was washed twice with MeOH
5. concentrationThe solution was concentrated in vacuo