Ammonium Chloride → HCID 67469271, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [2-(2-chloro-4-nitro-phenyl)ethyl]-(4-fluoro-benzyl)-carbamic acid tert-butyl ester (0.6 g, 1.4 mmol) in methanol (18 mL) was added a saturated solution of NH4Cl (18 mL), followed by zinc powder (0.41 g, 7.3 mmol) and the reaction mixture was heated at 45° C. for 1 hour. The reaction mixture was cooled to RT, filtered and EtOAc (60 mL) and water (100 mL) were added to the filtrate and the mixture was stirred for 15 minutes. The separated organic phase was washed with water (80 mL), brine (80 mL), dried (Na2SO4) and the solvents removed under reduced pressure to afford the title compound (0.49 g, 88%).

Provenance & Evidence