反应详情

To a solution of tert-butyl 2-(2-chloro-4-nitrophenoxy)ethyl-(2,4-difluorobenzyl)-carbamate (1.8 g, 4.06 mmol) in 70% aqueous ethanol (30 mL) was added sodium dithionite (2.87 g, 16.25 mmol), and the reaction mixture was heated to reflux for 3 hours. The hot reaction mixture was filtered and the residue washed with EtOAc (30 mL). The combined organic extracts were washed with brine (2×20 mL), dried (Na2SO4) and concentrated to give the title product (1.6 g, 95%) which was used in the next step without further purification.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 3 hours
3. filtrationThe hot reaction mixture was filtered
4. washthe residue washed with EtOAc (30 mL)
5. washThe combined organic extracts were washed with brine (2×20 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated