反应详情

To a solution of 1-(2-bromoethyl)-2-chloro-4-nitrobenzene (0.6 g, 1.84 mmol) in DMSO (20 mL), 3-chlorobenzylamine (1.21 g, 4.61 mmol) was added at room temperature. The reaction mixture was stirred for 3 hours at room temperature. After the completion of reaction, water (80 mL) was added and reaction mass was extracted with EtOAc (2×50 mL). The combined organic extracts were washed with water (50 mL), brine (50 mL) and the solvents removed under reduced pressure. The product was purified by column chromatography on neutral silica gel using 5-15% EtOAc in hexane to give the title compound (0.43 g, 55%) as a solid.

1. additionwas added
2. customreaction mass
3. extractionwas extracted with EtOAc (2×50 mL)
4. washThe combined organic extracts were washed with water (50 mL), brine (50 mL)
5. customthe solvents removed under reduced pressure
6. customThe product was purified by column chromatography on neutral silica gel using 5-15% EtOAc in hexane