Dimethylformamide → HCID 71294279, compound

Participants

Reaction Steps

A solution of tert-butyl 4-amino-2-chloro-5-methoxyphenethyl(3-fluorobenzyl)-carbamate (0.3 g, 0.74 mmol) and phenyl-5-chloropyrazin-2-ylcarbamate (0.18 g, 0.74 mmol) in DMF (30 mL) was heated to 100° C. for 2 hours. The mixture was partitioned between water (200 mL) and EtOAc (50 mL) and the separated aqueous layer was extracted with EtOAc (50 mL). The combined organic extracts were washed with water (200 mL), brine (200 mL), dried (Na2SO4) and concentrated under reduced pressure. The crude product was purified by column chromatography on neutral silica gel using 20-30% EtOAc in hexane to give the title compound (0.19 g, 47%) as a solid.

Provenance & Evidence