Hydrochloric Acid → HCID 67465970, compound

Participants

Reaction Conditions

Reaction Steps

A solution of HCl in 1,4-dioxane (0.5 mL) was added to a solution of tert-butyl 2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenethyl(3-fluorobenzyl)carbamate (0.22 g 0.4 mmol) in DCM (30 mL) at 0° C. and the mixture stirred at 10° C. for 2 hours. The solvents were removed under reduced pressure to leave a solid residue that was washed with methanol (2×5 mL) and dried under reduced pressure to give the title compound (100 mg, 51%) as an off-white solid.

Provenance & Evidence