HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Thiophen-2-yl)-1,2-oxazole-3-carboxylic acid → 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Thiophen-2-yl)-1,2-oxazole-3-carboxylic acid | HCID 3157098 | — |
| Reactant | 1-[2-(7-Methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-ylamine | HCID 66747469 | — |
| Product | 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-amide | HCID 46852071 | — |
Reaction Steps
The title compound is prepared as a yellow solid (39 mg, 30% yield) following Scheme 1 and in analogy to Example 1 using 5-thiophen-2-yl-isoxazole-3-carboxylic acid (51 mg, 0.26 mmol 1.0 eq) and 1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-ylamine (80 mg, 0.26 mmol, 1.0 eq) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716280B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-301553494db64df9819fd5619781916e |
| Source note | uspto-grants-2014_05 |