HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-1-propanol → 6-({1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-piperidin-3-ylamino}-methyl)-4H-benzo[1,4]thiazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Reactant | 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde | HCID 10943348 | — |
| Reactant | 2-Chloro-7-methoxyquinoxaline | HCID 12686415 | — |
| Product | 6-({1-[3-(7-methoxy-quinoxalin-2-yloxy)-propyl]-piperidin-3-ylamino}-methyl)-4H-benzo[1,4]thiazin-3-one | HCID 66746141 | — |
Reaction Steps
The title compound is prepared as a yellow amorphous lyophilizated solid following Scheme 1 and in analogy to Examples 1 and 9 using 2-chloro-7-methoxy-quinoxaline, 3-bromo-propan-1-ol, piperidin-3-yl-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716280B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-73c70059149e42d9bf95e59f8994e2e2 |
| Source note | uspto-grants-2014_05 |