3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 66746999, compound

HRID 1019878Notes

Reaction equation

HRID 1019878 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([N+:12]([O-:14])=[O:13])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:20](=[O:31])[NH:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[N+:12]([C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:30][CH2:29][CH2:28][N:25]3[CH2:24][CH2:23][CH:22]([NH:21][C:20]([C:40]4[CH:41]=[CH:42][C:36]5[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:31])[CH2:27][CH2:26]3)=[N:3]2)=[CH:8][CH:7]=1)([O-:14])=[O:13]

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 40547802-chloro-7-nitroquinoxalineHCID 45076484[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 66746999HCID 66746999, compound

Procedure

The title compound is prepared as a yellow lyophilizated powder following Scheme 1 and in analogy to Examples 1 and 12 using 2-chloro-7-nitro-quinoxaline, [1-(2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-85cb36e956694304ab7aa2f512c35ed2
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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